The SWI/SNF chromatin remodelling complex: Its role in
Aug 01, 2015 · The BAF complex either contains the BRG1 or BRM catalytic subunit, while the PBAF complex always contains BRG1. In addition to the catalytic subunit, each complex contains a number of shared 'core 2 PHD fingers: including the cohesin loader components Scc2 and Scc4, and the cohesion establishment factors Eco1, Scc3, Pds5, and Wapl. In
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SCC2 …
69,Gregory CopenhaverPLOS Genetics"The cohesin loader SCC2 contains a PHD finger that is required for meiosis in land plants",SCC2。
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Post-translational Regulation of DNA Polymerase η, a
Dec 01, 2020 · Cohesin complexes are loaded on DNA before replication onset through the action of the cohesin loader Scc2-Scc4 (Ciosk et al. 2000). The canonical function of cohesin is to generate sister chromatid cohesion during S phase, which is maintained until anaphase ( Nasmyth and Haering 2009 ; Peters and Nishiyama 2012 ; Uhlmann 2016 ).
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Greg Copenhaver - Associate Dean, Research and Innovation
Ph.D. Biology and Biomedical Sciences. The cohesin loader SCC2 contains a PHD finger that is required for meiosis in land plants PLoS Genet 16(6): e1008849. https: //doi
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The Arabidopsis homolog of Scc4/MAU2 is essential for
Jan 30, 2017 · The cohesin loader SCC2 contains a PHD finger that is required for meiosis in land plants. Wang H, Xu W, Sun Y, Lian Q, Wang C, Yu C, He C, Wang J, Ma H, Copenhaver GP, Wang Y. PLoS Genet, 16(6):e1008849, 09 Jun 2020 Cited by: 1 article | PMID: 32516352 | PMCID: PMC7304647
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DNA loop extrusion by human cohesin
How cohesin forms loops and TADs is unknown, but one hypothesis posits that cohesin extrudes DNA loops until it encounters convergently oriented "loop anchor" DNA sequences that are bound by the zinc finger protein CTCF (12, 13).This hypothesis could explain why cohesin and CTCF colocalize (14, 15) at TAD boundaries (1, 2) and loop anchors (), why these contain CTCF sites in convergent
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Yingxiang Wang - Publications
The cohesin loader SCC2 contains a PHD finger that is required for meiosis in land plants. Plos Genetics. 16: e1008849. PMID
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The plant adherin AtSCC2 is required for embryogenesis and
Jun 11, 2020 · The cohesin loader SCC2 contains a PHD finger that is required for meiosis in land plants. Cohesin, a multisubunit protein complex, is required for holding sister chromatids together during mitosis and meiosis. The recruitment of cohesin by the sister chromatid cohesion 2/4 (SCC2/4) complex has been extensively studied in Saccharomyces cerevisiae mitosis, but its role in mitosis and meiosis …
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The Arabidopsis Information Resource | BiŌkeanós
PMID:32541953 The cohesin loader SCC2 contains a PHD finger that is required for meiosis in land plants. PMID:32516352 What Can Long Terminal Repeats Tell Us About the Age of LTR Retrotransposons, Gene Conversion and Ectopic Recombination? PMID:32508870 NATpare: a pipeline for high-throughput prediction and functional analysis of nat-siRNAs.
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The cohesin loader SCC2 contains a PHD finger that is
The cohesin loader SCC2 contains a PHD finger that is required for mei…
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Cong Wang - Publications
The cohesin loader SCC2 contains a PHD finger that is required for meiosis in land plants. Plos Genetics. 16: e1008849. PMID 32516352 DOI: 10.1371/Journal.Pgen.1008849 : 0.36: 2020: Shen N, Wang Z, Wang C, Zhang J, Liu C. Methane Alleviates Inflammation and Apoptosis of Dextran Sulfate Sodium-Induced Inflammatory Bowel Diseases by Inhibiting
Get a quoteSensitivity of cohesin–chromatin association to high-salt
Jul 28, 2021 · In the proposed scenario, the Pds5–Wapl complex, rather than Scc2, serves as an actual cohesin loader in vivo. Such activity has been indeed demonstrated in vitro [ 45 ]. The Scc2 in vitro loading activity shown in several studies is likely to rely on the same process of …
Get a quoteSCC2 - Sister chromatid cohesion protein SCC2
Jun 12, 2007 · View protein in InterPro IPR016024, ARM-type_fold IPR026003, Cohesin_HEAT IPR024986, Nipped-B_C IPR033031, SCC2/Nipped-B IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD: PANTHER i: PTHR21704, PTHR21704, 1 hit
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Cong Wang's research works | Fudan University, Shanghai
The cohesin loader SCC2 contains a PHD finger that is required for meiosis in land plants
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The cohesin loader SCC2 contains a PHD finger that is
The cohesin loader SCC2 contains a PHD finger that is required for mei…
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SCC2 …
Jun 15, 2020 · 6 9, Gregory Copenhaver PLOS Genetics " The cohesin loader SCC2 contains a PHD finger that is required for meiosis in land plants ", SCC2 。
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Alternative catalytic residues in the active site of Esco
Sep 13, 2019 · Additionally, cohesin facilitates postreplicative homologous recombination repair of double-strand DNA breaks, and regulates gene expression via the formation of chromatin loops 5-9. Cohesin is loaded onto chromatin by the Scc2-Scc4 loader complex and released by Wapl and Pds5 10-15. Both cohesin loading and unloading
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Scc2 counteracts a Wapl-independent mechanism that
Jun 21, 2019 · Cohesin's association with chromosomes is determined by loading dependent on the Scc2/4 complex and release due to Wapl. We show here that Scc2 also actively maintains cohesin on chromosomes during G1 in S. cerevisiae cells. It does so by blocking a Wapl-independent release reaction that requires opening the cohesin ring at its Smc3/Scc1 interface as well as the D loop of …
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Structural Basis of Eco1-Mediated Cohesin Acetylation
Mar 14, 2017 · The topological entrapment of chromosomes by cohesin (Smc1, Smc3, Scc1, and Scc3) is central to genome integrity 1,2,3.Cohesin is loaded onto …
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Frontiers | In Favor of Establishment: Regulation of
May 23, 2017 · The specific function of SCC2/SCC4 during loading of the cohesin complexes is unclear, but they may activate or prime the ATPase activity of SMC proteins, somehow allowing cohesin rings to entrap chromosomes (Haering et al., 2002; Arumugam et al., 2003; Gruber et al., 2003, 2006; Seitan et al., 2006). This behavior has been inferred from mutant
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